Are Antidiabetic Drugs Dangerous?

Dangerous Drugs

Antidiabetic and antimalarial biguanide drugs are metal-interactive antiproteolytic agents.

Various biguanide derivatives are used as antihyperglycemic and antimalarial drugs (e.g., 1,1-dimethyl biguanide (metformin), phenylethyl biguanide (phenformin), N-(4-chlorophenyl)-N'-(isopropyl)-imidodicarbonimidic diamide (proguanil)); however, no common mechanism has been suggested in these controversial therapeutic actions. Biguanides bind endogenous metals that inhibit cysteine proteases i...

Hospitals and Dangerous Drugs

Newer Antidiabetic Drugs

The current oral blood glucose lowering agents and dietary measures only partially correct the multiple metabolic defects in NIDDM with insulin resistance remaining relatively impervious to treatment Hypoglycaemia and secondary failure are common with presently available sulphonylureas and hence the need for newer blood glucose lowering drugs. In case of NIDDM, a successful new drug should corr...

Are Radiation Exposure Levels Used in Cardiology Dangerous?

Background: The number of interventional cardiology procedures performed has increased rapidly over the past years. While these procedures help physicians avoid using highly complicated invasive methods, it usually leads to high levels of exposure to ionizing radiation of both patients and cardiologist. The dose received by the cardiologist during interventional cardiology procedures is determi...